Education： Doctorate University: Nanjing Agricultural University, China Date: June, 29th 2016 Supervisor: Zhang Haibin Title of thesis: Molecular Regulation of Interferons, P53 and Pattern Recognition Receptors mediated Antiviral Innate Immune Response by Chicken Cellular miRNA Professional Experience： From 2016 – to date Associate professor, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences From 2012 to 2016 Assistant professor, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences From 2009 to 2012 Research assistant, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Science In 2016, I became Associate professor. Scientific Research Field： I am mainly engaged in research on prevention and control of Infection bursal disease virus(IBDV), which causes severe immunosuppressive disease in young chickens and continues to pose a significant threat to the poultry. My research content includes two aspects: in the aspect of application research, mainly engaged in the research of IBDV genetic engineering vaccine, the development of IBDV monoclonal antibody and the development of IBDV antibody competitive ELISA detection kit; In the basic research of IBDV, I mainly studied the molecular mechanism of miRNA anti-IBDV innate immunity in chickens, the molecular mechanism of IBDV antagonistic cell RNAi and the molecular mechanism of IBDV regulating cell miRNA antagonistic cell interferon expression. Social academic post and honor： From 2018–to date Youth top talent of Jiangsu academy of agricultural sciences Teaching Courses： Published papers： 1．Wei Ouyang, Yong-shan Wang*, Kai Meng, Qun-xing Pan, Xiao-li Wang, Xing-xia Xia, Yu-mei Zhu, Zhen-wei Bi, Chen-hong Dong, Hai-bin Zhang*. gga-miR-2127 down regulates the translation of chicken p53 and attenuates chp53-mediated innate immune response against IBDV infection. Veterinary Microbiology (Vet Microbiol), 2017,198:34-42 2．Wei Ouyang, Yong-shan Wang*, Xi-ning Du, Hua-jie Liu, Hai-bin Zhang*. gga-miR-9* inhibits IFN production in antiviral innate immunity by targeting interferon regulatory factor 2 to promote IBDV replication. Veterinary Microbiology, 2015, 178(1-2):41-49 3．Yong-shan Wang*, Wei Ouyang, Qun-xing Pan, Xiao-li Wang, Xing-xia Xia, Zhen-wei Bi, Yong-qiang Wang, Xiao-mei Wang*. Overexpression of microRNA gga-miR-21 in chicken fibroblasts suppresses replication of infectious bursal disease virus through inhibiting VP1 translation. Antiviral Research, 2013, 100(1): 196-201 4．Wei Ouyang, Jin-rong Ma, Yong-qiang Wang, Li-ting Qin, Jie-yuan Jiang, Hong-jie Fan, Xiao-mei Wang*, Yong-shan Wang*. Reduction of infectious bursal disease virus replication by shRNAs targeting the VP1 and VP2 genes driven by chicken U6 promoter. Veterinary Microbiology (Vet Microbiol.), 2013, 162: 44-52 5．Yong-shan Wang, Wei Ouyang, Xiao-juan Liu, Kong-wang He, Sheng-qing Yu, Hai-bin Zhang, Hong-jie Fan, Cheng-ping Lu. Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV. Vaccine, 2012, 30(12): 2125-2130 Main Scientific Research Projects： 1.2018 National Natural Science Foundation of China, entitled “ Molecular mechanism of suppression of antiviral RNA interference by infectious bursal disease virus in DF-1 cells (Grant No. 31772723 )”. (2018-2021; Budget ¥ 720,000) 2.2014 National Natural Science Foundation of China，entitled “Molecular mechanism of miRNA regulates the p53 anti-infectious bursal disease virus immunity(Grant No. 31302070 ) ”(2014-2016; Budget ¥ 200,000) 3.2017 The National Key Research and Development Program of China, entitled “ Application of optimized cell to impove the yield of IBDV(Grant No. 2017YFD0500706 )”. (2017-2020; Budget ¥ 275,000） 4.2015 Jiangsu Provincial Natural Science Foundation of China，entitled “Molecular mechanism of Infectious bursal disease virus interferes with pattern recognition receptor mediated antiviral innate immunity(Grant No. BK20141381 )”(2015-2017; Budget ¥100,000) 5.2010 Jiangsu Provincial Natural Science Foundation of China，entitled “Analysis and functional study on microRNA of B lymphocytes infected with IBDV(Grant No. BK2010471 )”(2010-2013; Budget ¥ 100,000) 6.2014 Jiangsu Agriculture Science and Technology Innovation Fund (JASTIF)，entitled “Molecular mechanism of Infectious bursal disease virus interferes with pattern recognition receptor mediated antiviral innate immunity(Grant No. CX(14)5040 )”(2014-2016; Budget ¥ 100,000) 7.2013 Jiangsu Agriculture Science and Technology Innovation Fund (JASTIF)，entitled “Molecular mechanism of miRNA regulates the p53 anti-infectious bursal disease virus immunity(Grant No. CX(13)5032 )”(2013-2015; Budget ¥ 200,000) Patents： 1.Chicken embryo fibroblast passage cell lines with high expression of gga-mir-9 *, Chinese invention patent ZL201310565243.5, File Date: Dec 12, 2015, By Wei Ouyang , Yongshan Wang , Qunxing Pan , Xiaoli Wang , Xingxia Xia , Huajie Liu , Haibin Zhang. 2.Construction and application of the plasmid containing dual chU6 promoter and dual shRNA expression , Chinese invention patent ZL201110127319.7, File Date: Jau 9, 2013, By Wei Ouyang , Yongshan Wang , Jinrong Ma , Haibin Zhang. Scientific Research Achievements and Awards： Number of postgraduates under supervision Number of supervised masters and Ph.D. Number of supervised undergraduates The above information updated Apr. 2021 | 