代表性论文： [1] Chongxin Xu*, Jiafeng Jin, Wei Chen, Jianxing Shen, Youpeng Lai*, Yuan Liu, Xiao Zhang, Qing Zhu, Xianjin Liu. Dual-receptors traction-based directional design of a novel anti-idiotypic insecticidal antibody for simulating Bacillus thuringiensis Cry toxin against Plutella xylostella[J]. Pest Management Science. 2026. DOI: 10.1002/ps.70642. [2] Chongxin Xu*, Jianxing Shen, Ji Sun, Wei Chen, Yuan Liu, Xiao Zhang, Qing Zhu, Xianjin Liu. Establishment of a novel genetically engineered antibody-based immunoassay with broad-spectrum and high-sensitivity for monitoring Bacillus thuringiensis Cry-type toxins in food samples[J]. Food Research International, 2025, 221: 117524 [3] Chongxin Xu*, Yajun Qiu, Cheng Shen, Yajing Xie, Xin He, Xiaoming Sun, Ji Sun, Jianxing Shen, Yan Shen*. Directed design of anti-idiotypic nanobody with antibacterial activity against foodborne Staphylococcus aureus and its innovative application in green immunoassay[J]. ACS Synthetic Biology, 2025, 14, 3671-3686 [4] Chongxin Xu*, Jianxing Shen, Wei Chen, Xiaoming Sun, Xiao Zhang, Yuan Liu, Xianjin Liu. Targeting design of human anti-idiotypic genetically engineered antibody for simulating the structure and insecticidal function of Bt Cry 1C toxin[J]. Journal of Agricultural and Food Chemistry, 2024, 72(39): 21650-21666. [5] Chongxin Xu*, Dan He, Yao Zu, Sujuan Hong, Jia Hao, Jianhong Li*. Microcystin-LR heterologous genetically engineered antibody recombinant and its binding activity improvement and application in immunoassay[J]. Journal of Hazardous Materials, 2021, 406: 124596. [6] Chongxin Xu, Xiaoqin Liu, Yuan Liu, Xiao Zhang, Cunzheng Zhang, Jianhong Li*, Xianjin Liu*. High sensitive single chain variable fragment screening from a microcystin-LR immunized mouse phage antibody library and its application in immunoassay[J]. Talanta, 2019, 197: 397-405. [7] Jianxing Shen, Cheng Shen, Mengyuan Zhang, Haiyan Lu, Luo Na, Wei Chen, Xiao Zhang, Qing Zhu, Yuan Liu, Xianjin Liu, Chongxin Xu*. Establishment of multiple highly sensitive immunoassay platforms for detecting Bacillus thuringiensis Cry1Ah insecticidal protein in agricultural and food samples[J] International Journal of Biological Macromolecules, 2026: 149895. [8] Mengyuan Zhang, Jiafeng Jin, Wei Chen, Jianxing Shen, Na Luo, Yuan Liu, Xiao Zhang, Qing Zhu, Cheng Shen, Xianjin Liu*, Chongxin Xu*. Establishment of antibodies-based novel multi-modal highly sensitive immunoassay platforms for detecting Bacillus thuringiensis Vip3Aa toxin in agricultural samples[J]. Analytical and Bioanalytical Chemistry, 2026, DOI: https://doi.org/10.1007/s00216-026-06401-9. [9] 徐重新*，沈建兴，金嘉凤，何鑫，谢雅晶，张霄，朱庆，刘媛，刘贤金. 基因工程抗体功能修饰及其在农业食品安全中的应用策略[J]. 中国农业科学, 2025, 58(2):355-386. [10] 徐重新*, 金嘉凤, 孙晓明, 沈成, 张霄, 陈澄宇, 刘贤金, 刘媛*. 基于Bt毒素的杀虫蛋白理性设计与创新应用策略[J]. 中国农业科学, 2024, 57(1): 96-125. |
[1]一种具备模拟Bt Cry1C毒素结构和杀虫功能的人源基因工程抗体及其突变体, 2025, 中国, ZL202411182418.9. (徐重新、沈建兴、陈蔚、谢雅晶、沈成、刘媛、张霄、刘贤金) [2]一种模拟Bt Cry毒素共性结构和功能的多肽及其编码基因与应用, 2024, 中国, ZL202310192513.6. (徐重新、刘媛、金嘉凤、沈成、陈蔚、胡晓丹、谢雅晶、张霄、朱庆) [3]一种模拟Bt Cry1Ac蛋白关键抗虫功能表位的短肽及其编码基因与应用, 2023, 中国, ZL202111397024.1 (徐重新、刘贤金、高美静、胡晓丹、刘媛、仲建锋、谢雅晶、张霄) [4]一种人源化抗金黄色葡萄球菌生物活性肽及其编码基因与应用, 2022, 中国, ZL202010779437.5 (徐重新、刘贤金、谢雅晶、林曼曼、胡晓丹、刘媛、张霄、仲建锋、朱庆) [5] Anthropogenic pest-resistant gene, anti-Cry1Ab toxin idiotypic single-chain antibody encoded by same, and application，2017，US 9，751，952 B2（美国PCT专利）(刘贤金、徐重新、张霄、刘媛、谢雅晶、张存政、余向阳、王冬兰) [6] Human-derived insect-resistant gene and anti-Cry1B toxin idiotype single-chain antibody encoded thereby and application thereof，2017，US 9，770，038 B2（美国PCT专利）(刘贤金、徐重新、张霄、刘媛、谢雅晶、张存政、余向阳、王冬兰) [7] Human-derived insect-resistant gene and anti-CrylC toxin idiotype single-chain antibody encoded thereby and application thereof，2017，US 9，745，385 B2（美国PCT专利）(刘贤金、徐重新、张霄、刘媛、谢雅晶、张存政、余向阳、王冬兰) |
