Education B.S.A., Veterinary medicine Hebei Agricultural University 1996-2000 M.S., Basic Veterinary medicine Nanjing Agricultural University 2000-2003 Ph.D., Preventive Veterinary Medicine Nanjing Agricultural University 2007-2011 Professional Experience Research assistant, Preventive Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 2003.9-2006.8 Assistant Professor, Preventive Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 2006.9-2010.8 Associate Professor, Preventive Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 2010.9-2017.8 Visiting scholar, Texas A&M University, College station, 2012.7-2013.7 Visiting scholar, Kansas State University, Manhattan, 2015.7-2016.7 Professor, Preventive Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 2017.9-present Scientific Research Field My laboratory is interested in etiology, drug resistance and research and development of control technology on E.coli, involving shiga toxin E.coli (STEC), enterotoxin E.coli (ETEC), extraintestinal pathogenic E.coli (ExPec). The detailed research direction: ①The epidemic and genetic evolution of E.coli in farm and slaughtering process; ②Analysis of E.coli resistance, investigation of resistance mechanism and development of alternatives for antibiotics; ③Study on rapid detection and prevention and control technology of E.coli; ④Study on mucosal adjuvant and its mechanism. Social academic post and honor Teaching Courses Published papers (1)Zhang X*, Zhang B, Guo Y, Wang J, Zhao P, Liu J, He K. Colistin resistance prevalence in Escherichia coli from domestic animals in intensive breeding farms of Jiangsu Province, Int J Food Microbiol., 2018 ,291:87-90. (2)Zhang B, Sun X, Fan H, He K, Zhang X*. The Fimbrial Gene z3276 in Enterohemorrhagic Escherichia coli O157:H7 Contributes to Bacterial Pathogenicity, Frontiers in Microbiology, 2018, 9:1628. (3)Zhang X, Li M, Zhang B, Chen K, He K. Development of a Sandwich ELISA for EHEC O157:H7 Intimin γ1, PLoS ONE, 2016, 11(9):e0162274. (4)Yang M, Zhang C, Zhang X, Zhang M, Rottinghaus G, Zhang S. Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges. BMC Microbiol., 2016,16:210. (5)Zhang X, Yu Z, Zhang S, He K. Immunization with H7-HCP-tir-intimin significantly reduces colonization and shedding of Escherichia coli O157:H7 in goats. PLoS One, 2014 9(3):e91632. (6)Zhou J, Zhang X, He K, Wang W, Ni Y, Zhu H, Yu Z, Mao A, Lv L. Characterization and proteome analysis of inosine 5-monophosphate dehydrogenase in epidemic Streptococcus suis serotype 2. Curr Microbiol., 2014, 68(5):663-669. Main Scientific Research Projects (1)2018YFD0500504 Zhang xuehan (PI) 06/01/2018-12/31/2020 National Key Research and Development Program of China: Study on the prevalence and spread of important foodborne pathogenic microorganisms in cattle and sheep breeding, slaughtering and milk production. (2)BE2017341-1 Zhang xuehan (PI) 06/01/2017-12/31/2020 Jiangsu Key Research and Development plan: Research on key technologies for prevention and control of pathogenic Escherichia coli in animal-derived foods (3)31572503 Zhang xuehan (PI) 01/01/2016-12/31/2019 National Natural Science Foundation: Study on the molecular mechanism on inhibiting lectin complement activation system by interaction of ficolin 3 with HCP from EHEC O157:H7 (4)Cx(15)1060 Zhang xuehan (PI) 07/01/2015-06/30/2018 Exploration foundation in Jiangsu Province: Construction mucosal carrier of flagellar from non-pathogenic E. coli and its application in developing vaccine for foot-and-mouth disease (FMDV). (5)2014-S17 Zhang xuehan (PI) 01/01/2014-12/31/2014 Ministry of Agriculture “948”project: Development of universal vaccine for Enterotoxic Escherichia coli (6)31201919 Zhang xuehan (PI) 01/01/2013-12/31/2015 National Natural Science Foundation: Screening and identification of host proteins interacted with EHEC O157: H7 Ⅳ pili. Patents (1)Zhang Xuehan, Yu Zhengyu, Zhang Qiang, Zhang Bicheng, Wang Wei, Mao Aihua, Zhou Junming, He Kongwang, Ni Yanxiu, Wen Libin, Li Bin, Zhou Ping. Fusion protein, preparation method and its application for detecting enterotoxin-producing Escherichia coli antibody from pig, 2018, 3, China, ZL201510481575.4. Jiangsu Academy of Agricultural Sciences. (2)Zhang Xuehan, He Kongwang, Li Meng, Wang Wei, Ni Yanxiu, Wen Libin, Li Bin. PCR detection primers and detection kit for Enterohemorrhagic Escherichia coli O157:H7, 2016, 4, China, invention patent ZL201410130211.7. Jiangsu Academy of Agricultural Sciences. (3)Zhang Xuehan, He Kongwang, Yan Xiaoting, Li Meng, Wang Wei, Wen Libin, Li Bin, Ni Yanxiu. A primer and probe sequence for detecting a nucleic acid fragment of Enterohemorrhagic Escherichia coli O157H7, 2015, 8, China, invention patent ZL201410132107.1. Jiangsu Academy of Agricultural Sciences. (4)Zhang Xuehan, Wang Wei, He Kongwang, Ni Yanxiu, Wen Libin, Li Bin, Zhou Junming, Wang Xiaomin. E. coli O157:H7LAMP detection primer and detection kit, 2015, 10, China, invention patent ZL201410130191.3. Jiangsu Academy of Agricultural Sciences. (5)Zhang Xuehan, He Kongwang, Ye Qing, Wen Libin, Guo Rongli, Li Bin, Wang Xiaomin, Ni Yanxiu, Lu Lixin, Zhou Junming, Yu Zhengyu, Mao Aihua, Zhou Ping, Shen Jiangping. Multivalent fliC-hcpA-tir-eae recombinant strain and vaccine for Enterohemorrhagic Escherichia coli O157:H7, 2016, 3, China, ZL201310099542.4. Jiangsu Academy of Agricultural Sciences. (6)He Kongwang, Zhang Xuehan, Lu Weicai, Zhao Pandeng, Ye Qing, Wen Libin, Guo Rongli, Li Bin, Wang Xiaomin, Ni Yanxiu, Lu Lixin, Zhou Junming, Yu Zhengyu, Mao Aihua, Zhou Ping, Shen Jiangping. Enterohemorrhagic Escherichia coli O157:H7 three gene deletion strain, 2013, 5, China, ZL201110087699.6. Jiangsu Academy of Agricultural Sciences. (7)Lu Lixin, Zhou Junming, Zhang Xuehan, Mao Aihua, He Kongwang, Ni Yanxiu, Qi Feng, Zhu Yudan, Yu Zhengyu, Wen Libin, Li Bin, Guo Rongli, Wang Xiaomin, Wang Wei, Zhou Ping, Shen Jiangping. A non-toxic ST28 Streptococcus suis and its application, 2014, 1, China, ZL201210413985.1. Jiangsu Academy of Agricultural Sciences. (8)Zhang Xuehan, He Kongwang, Lu Weicai, Zhao Pandeng, Wen Libin, Guo Rongli, Li Bin, Wang Xiaomin, Ni Yanxiu, Lu Lixin, Zhou Junming, Yu Zhengyu, Mao Aihua, Zhou Ping, Shen Jiangping. Enhanced mucosal immune multivalent fusion recombinant bacteria and vaccine for Enterohaemorrhagic Escherichia coli O157:H7, 2012,12, China, ZL201010118490.7. Jiangsu Academy of Agricultural Sciences. (9)He Kongwang, Zhang Xuehan, Lu Weicai, Zhao Pandeng, Wen Libin, Guo Rongli, Li Bin, Wang Xiaomin, Ni Yanxiu, Lu Lixin, Zhou Junming, Yu Zhengyu, Mao Aihua, Zhou Ping, Shen Jiangping. Construction of Tir and Tccp recombinant protein from Enterohaemorrhagic Escherichia coli O157:H7 2012, 4, China, ZL201010118499.8. Jiangsu Academy of Agricultural Sciences. (10)Wang Yongshan, Liu Jie, Xia Xingxia, He Kongwang, Zhang Xuehan, Fei Rongmei. Mouse serum antibody colloidal gold immunochromatographic test strip for Enterohaemorrhagic Escherichia coli O157:H7, 2012, 10, China, ZL200910181759.3. Jiangsu Academy of Agricultural Sciences. Scientific Research Achievements and Awards Lu Lixin, Zhou Junming, Zhang Xuehan, Mao Aihua, He Kongwang, Ni Yanxiu, Qi Feng, Zhu Yudan, Yu Zhengyu, Wen Libin, Li Bin, Guo Rongli, Wang Xiaomin, Wang Wei, Zhou Ping, Shen Jiangping. A non-toxic ST28 Streptococcus suis and its application, 2014, 1, China, ZL201210413985.1. This patent was sold for10 million yuan. Number of postgraduates under supervision 2 Number of supervised masters and Ph.D. 16, including 2 Ph.D students Number of supervised undergraduates 39 The above information updated Mar.2019 |
