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讲准字312号:食品的生物活性和化学环境在肥胖症和二型糖尿病发展中的作用Role of Food Bioactives and Environmental contaminants in Development of Obesity and Type 2 Diabetes

题目:食品的生物活性和化学环境在肥胖症和二型糖尿病发展中的作用Role of Food Bioactives and Environmental contaminants in Development of Obesity and Type 2 Diabetes

主讲:Yeonhwa Park

时间:112日上午930

地点:会议中心第三报告厅

主办:食品与生物工程学院

  主讲简介:

Yeonhwa Park教授在美国威斯康辛大学取得博士学位并接受了博士后训练。现任马萨诸塞大学正教授, 研究生项目主任以及F.J. Francis Endowed Chair。主要从事食品功能因子调节改善糖脂代谢机制以及食品污染物诱导脂肪积累和胰岛素抵抗的机制研究。荣获20142017年全球高被引科学家(Thomson Reuters & Clarivate)(农业科学领域)。Park教授在Annual Review of Food Science and TechnologyCritical Reviews in Food Science and NutritionJournal of Agricultural and Food Chemistry, Journal of Nutritional Biochemistry, Food Chemistry, Food & FunctionFood and Chemical Toxicology等国际一流期刊发表120多篇论文(引用6700余次)。目前担任一流SCI期刊(Food and Chemical Toxicology)副主编;荣获2015美国油脂化学学会Timothy Mounts 奖,马萨诸塞大学杰出教师奖,国际生命科学学会(ILSI)奖, 2007 北美未来科学领袖奖,美国食品技术协会(IFT)杰出服务奖,美国油脂化学协会青年科学家等奖项。

主讲内容:

Many food components and environmental contaminants are known to influence the development of obesity and type 2 diabetes. Among food bioactives, interest in conjugated linoleic acid (CLA) research started in the 1980s because it was identified as an anti-carcinogenic compound from ground beef. CLA is a collective term for geometric and positional isomers of conjugated octadecadienoic acid, consisting mainly of two isomers, cis-9,trans-11 and trans-10,cis-12. Since its discovery, CLA has been reported to have a wide range of biological activities, in particular its role on regulating body fat along with its influence on muscle and bone masss. On the other hand, the significant rise in the incidences of obesity and type 2 diabetes in the past few decades is not completely explained by concurrent changes in diet and/or behavior, suggesting there may be unknown contributing factors to this epidemic. Simultaneously, there is a growing body of evidence suggests a connection between exposure to environmental pollutants, including insecticides, and the development of obesity and type 2 diabetes. Consistently, recent publications reported that different types of insecticides have similar effects on altered lipid and glucose homeostasis at levels that are considered to be safe. Moreover, the augmented effects of insecticide exposures and other known factors on the development of obesity and type 2 diabetes were recently observed. Based on the current rise of obesity and its associated pathology, it is important to understand the underlying causes of obesity and type 2 diabetes and to develop means to mitigate these diseases.

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