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讲准字60号:过程分析技术(PAT)在结晶过程的应用

题目过程分析技术(PAT)在结晶过程的应用

Application ofprocess analytical technology(PAT) tools for the better understanding and control of crystallisation processes

主讲Elena Simone

时间:4月19日 下午2:30

地点:会议中心第三报告厅

主办:食品与生物工程学院

主讲简介:Elena Simone,现就职于英国利兹大学食品科学与营养学院。2011年毕业于意大利比萨大学获硕士学位,2015年毕业于英国拉夫堡大学获博士学位,曾赴美国普渡大学作访问学者,曾任联合利华研究科学家。Dr. Elena Simone发表论文11篇,被引用72次,h-index 5(Scopus,2016年11月)。其主要研究领域包括:基于在线、原位分析技术表征药物和食品晶体(例如脂肪,糖)的多态性,检测与控制晶体成核过程;探索食品安全检测的无损检测新技术;过程分析技术(PAT)在食品工业中的应用等。Dr. Elena Simone,目前担任EPSRC CP3博士生培养中心管理委员会成员,ESCAPE-27和ICNFS 2017会议技术委员会成员,曾担任EPSRC SOFI博士生培训中心博士论文内部审查员。

主讲内容:Crystallisation is an important unit operation used as separation and purification technique. It is widely employed in the pharmaceutical, chemical, agrochemical, food and cosmetics industries but also in the electronic, metallurgic and material industries.

More than 90% of the active pharmaceutical ingredients (APIs) on the market are produced by crystallisation and crystal size, shape and lattice structure (polymorphism) have a profound effect on the properties of the final drug as well as on the efficiency of the downstream operations (filtration, washing, drying, tableting etc.). Therefore, monitoring and control this process is fundamental to ensure the quality of the end product. The implementation of process analytical technology (PAT) tools during the development stage of APIs has largely helped in better understanding and optimizing both batch and, more recently, continuous crystallisation. Specific instrumentation can be used to monitor on-line, in situ, crystal size and shape (focused beam reflectance measurement, FBRM, particle vision and measurement, PVM, ultrasound), polymorphism (Raman, FTIR and NIR spectroscopy) and liquid phase composition (Attenuated total reflectance UV/VIS and FTIR, on-line HPLC) [1-3]. Furthermore, feedback control strategies based on PAT tools signal can be implemented in order to specifically tailor the characteristics of the produced crystals and gain higher product quality and process efficiency [4,5]. This work shows few examples of application of PAT tools for the study and control of crystallization processes.

Reference

[1] Duffy, D., Barrett, M., Glennon, B. (2013) Cryst. Growth Des., 13, 3321–3332.

[2] Povey, M. J. W. (2016) J. Chem. Phys., 145, 211906.

[3] Wang, X., Watcher, J. A., Antosz, F. J., Berglund, K. A. (2000) Org. Process Res. Dev., 4, 391–395.

[4] Simone, E., Saleemi, A. N., Tonnon, N., Nagy, Z. K. (2014) Cryst. Growth Des., 14(4), 1839–1850.

[5] Simone, E., Zhang, W., Nagy, Z. K. (2015) Cryst. Growth Des., 15(6), 2908–2919.

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